Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis

Gastrointestinal toxicity is the primary limiting factor in abdominal and pelvic radiotherapy, but has no effective treatment currently. We recently showed a critical role of the BH3-only protein PUMA in acute radiation-induced GI damage and GI syndrome in mice. Growth factors such as IGF-1 and bFGF...

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Bibliographic Details
Main Authors:	Qiu, Wei, Leibowitz, Brian, Zhang, Lin, Yu, Jian
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3076086/ https://ncbi.nlm.nih.gov/pubmed/19966853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.451
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Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis

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