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Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21
The role of p53 in tissue protection is not well understood. Loss of p53 blocks apoptosis in the intestinal crypts following irradiation, but paradoxically accelerates gastrointestinal (GI) damage and death. PUMA and p21 are the major mediators of p53-dependent apoptosis and cell cycle checkpoints,...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3096742/ https://ncbi.nlm.nih.gov/pubmed/21450905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0052 |
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