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The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage
The tumor suppressor p53 can induce apoptosis by activating gene expression in the nucleus, or by directly permeabilizing mitochondria in the cytoplasm. It has been shown that PUMA, a downstream target of p53 and a BH3-only Bcl-2 family member, plays an essential role in apoptosis induced by both nu...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1820707/ https://ncbi.nlm.nih.gov/pubmed/17360476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700020104 |
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