Gα(q) Signal in Osteoblasts Is Inhibitory to the Osteoanabolic Action of Parathyroid Hormone

This study examined the role of the Gα(q) signal constituted by Gα(q) and Gα(11) (encoded by Gnα(q) and Gnα(11), respectively), a major intracellular pathway of parathyroid hormone (PTH), in the PTH osteoanabolic action by the gain- and loss-of-function analyses. Transgenic mice with osteoblast-spec...

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Main Authors: Ogata, Naoshi, Shinoda, Yusuke, Wettschureck, Nina, Offermanns, Stefan, Takeda, Shu, Nakamura, Kozo, Segre, Gino V., Chung, Ung-il, Kawaguchi, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075717/
https://ncbi.nlm.nih.gov/pubmed/21345793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200196
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