Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover

Insulin receptor substrates (IRS-1 and -2) are essential for intracellular signaling by insulin and IGF-I, anabolic regulators of bone metabolism. Mice lacking the IRS-1 gene IRS-1(–/–) showed severe osteopenia with low bone turnover. IRS-1 was expressed in osteoblasts, but not in osteoclasts, of wi...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Ogata, Naoshi, Chikazu, Daichi, Kubota, Naoto, Terauchi, Yasuo, Tobe, Kazuyuki, Azuma, Yoshiaki, Ohta, Tomohiro, Kadowaki, Takashi, Nakamura, Kozo, Kawaguchi, Hiroshi
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 2000
Assuntos:	Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC377487/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10749573/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9017
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