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Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover

Insulin receptor substrates (IRS-1 and -2) are essential for intracellular signaling by insulin and IGF-I, anabolic regulators of bone metabolism. Mice lacking the IRS-1 gene IRS-1(–/–) showed severe osteopenia with low bone turnover. IRS-1 was expressed in osteoblasts, but not in osteoclasts, of wi...

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Published in:J Clin Invest
Main Authors: Ogata, Naoshi, Chikazu, Daichi, Kubota, Naoto, Terauchi, Yasuo, Tobe, Kazuyuki, Azuma, Yoshiaki, Ohta, Tomohiro, Kadowaki, Takashi, Nakamura, Kozo, Kawaguchi, Hiroshi
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2000
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC377487/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10749573/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9017
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