Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts

Insulin receptor substrates (IRS-1 and IRS-2) are essential for intracellular signaling by insulin and insulin-like growth factor-I (IGF-I), anabolic regulators of bone metabolism. Although mice lacking the IRS-2 gene (IRS-2 (−/−) mice) developed normally, they exhibited osteopenia with decreased bo...

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Hauptverfasser: Akune, Toru, Ogata, Naoshi, Hoshi, Kazuto, Kubota, Naoto, Terauchi, Yasuo, Tobe, Kazuyuki, Takagi, Hideko, Azuma, Yoshiaki, Kadowaki, Takashi, Nakamura, Kozo, Kawaguchi, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2002
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173484/
https://ncbi.nlm.nih.gov/pubmed/12379806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200204046
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