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Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts
Insulin receptor substrates (IRS-1 and IRS-2) are essential for intracellular signaling by insulin and insulin-like growth factor-I (IGF-I), anabolic regulators of bone metabolism. Although mice lacking the IRS-2 gene (IRS-2 (−/−) mice) developed normally, they exhibited osteopenia with decreased bo...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173484/ https://ncbi.nlm.nih.gov/pubmed/12379806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200204046 |
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