PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

Based on the fact that aging is associated with a reciprocal decrease of osteogenesis and an increase of adipogenesis in bone marrow and that osteoblasts and adipocytes share a common progenitor, this study investigated the role of PPARγ, a key regulator of adipocyte differentiation, in bone metabol...

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Bibliographische Detailangaben
Hauptverfasser: Akune, Toru, Ohba, Shinsuke, Kamekura, Satoru, Yamaguchi, Masayuki, Chung, Ung-il, Kubota, Naoto, Terauchi, Yasuo, Harada, Yoshifumi, Azuma, Yoshiaki, Nakamura, Kozo, Kadowaki, Takashi, Kawaguchi, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC362117/
https://ncbi.nlm.nih.gov/pubmed/15067317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419900
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