Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia

We recently identified a new gene, klotho, which is involved in the suppression of multiple aging phenotypes. The mouse homozygous for a disruption of the klotho locus (kl/kl) exhibited multiple pathological conditions resembling human aging. Histomorphometric analysis revealed low-turnover osteopen...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Kawaguchi, Hiroshi, Manabe, Noriyo, Miyaura, Chisato, Chikuda, Hirotaka, Nakamura, Kozo, Kuro-o, Makoto
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1999
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408412/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10430604/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI5705
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