Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model

Epigenetic therapy for solid tumors could benefit from an in vivo model that defines tumor characteristics of responsiveness and resistance to facilitate patient selection. Here we report that combining the histone deacetylase inhibitor entinostat with the demethylating agent vidaza profoundly affec...

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Hauptverfasser: Belinsky, Steven A., Grimes, Marcie J., Picchi, Maria A., Mitchell, Hugh D., Stidley, Chris A, Tesfaigzi, Yohannes, Channell, Meghan M., Liu, Yanbin, Casero, Robert A., Baylin, Stephen B., Reed, Mathew D., Tellez, Carmen S., March, Thomas H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075424/
https://ncbi.nlm.nih.gov/pubmed/21224363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3184
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