Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model

BACKGROUND: Epigenetic silencing by promoter methylation and chromatin remodelling affects hundreds of genes and is a causal event for lung cancer. Treatment of patients with low doses of the demethylating agent 5-azacytidine in combination with the histone deacetylase inhibitor entinostat has yield...

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Detalhes bibliográficos
Main Authors: Reed, M D, Tellez, C S, Grimes, M J, Picchi, M A, Tessema, M, Cheng, Y S, March, T H, Kuehl, P J, Belinsky, S A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790193/
https://ncbi.nlm.nih.gov/pubmed/24045660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.575
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