Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status

BACKGROUND: Epigenetic mechanisms have important roles in the tumour escape from immune responses, such as in MHC class I downregulation or altered expression of other components involved in antigen presentation. Chemotherapy with DNA methyltransferase inhibitors (DNMTi) can thus influence the tumou...

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Detalhes bibliográficos
Main Authors: Šímová, J, Polláková, V, Indrová, M, Mikyšková, R, Bieblová, J, Štěpánek, I, Bubeník, J, Reiniš, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242529/
https://ncbi.nlm.nih.gov/pubmed/22015556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.428
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