DNA-PKc deficiency drives pre-malignant transformation by reducing DNA repair capacity in concert with reprogramming the epigenome in human bronchial epithelial cells

The expression of DNA-dependent protein kinase catalytic subunit (DNA-PKc) is highly variable in smokers and reduced enzyme activity has been associated with risk for lung cancer. An in vitro model of lung pre-malignancy was used to evaluate the role of double-strand break DNA repair capacity in tra...

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Udgivet i:DNA Repair (Amst)
Main Authors: Teneng, Ivo, Picchi, Maria A., Leng, Shuguang, Dagucon, Christopher P., Ramalingam, Suresh, Tellez, Carmen S., Belinsky, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551272/
https://ncbi.nlm.nih.gov/pubmed/31055244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.04.006
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