Ryanodine Receptor Phosphorylation by CaMKII Promotes Life-Threatening Ventricular Arrhythmias in Mice with Heart Failure

BACKGROUND: Approximately half of patients with heart failure die suddenly as a result of ventricular arrhythmias. Although abnormal Ca(2+) release from the sarcoplasmic reticulum (SR) through ryanodine receptors (RyR2) has been linked to arrhythmogenesis, the molecular mechanisms triggering release...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: van Oort, Ralph J., McCauley, Mark D., Dixit, Sayali S., Pereira, Laetitia, Yang, Yi, Respress, Jonathan L., Wang, Qiongling, De Almeida, Angela C., Skapura, Darlene G., Anderson, Mark E., Bers, Donald M., Wehrens, Xander H.T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075419/
https://ncbi.nlm.nih.gov/pubmed/21098440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.982298
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