Ryanodine Receptor Phosphorylation by CaMKII Promotes Life-Threatening Ventricular Arrhythmias in Mice with Heart Failure

BACKGROUND: Approximately half of patients with heart failure die suddenly as a result of ventricular arrhythmias. Although abnormal Ca(2+) release from the sarcoplasmic reticulum (SR) through ryanodine receptors (RyR2) has been linked to arrhythmogenesis, the molecular mechanisms triggering release...

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Detalhes bibliográficos
Main Authors: van Oort, Ralph J., McCauley, Mark D., Dixit, Sayali S., Pereira, Laetitia, Yang, Yi, Respress, Jonathan L., Wang, Qiongling, De Almeida, Angela C., Skapura, Darlene G., Anderson, Mark E., Bers, Donald M., Wehrens, Xander H.T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075419/
https://ncbi.nlm.nih.gov/pubmed/21098440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.982298
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