Effects of CaMKII-Mediated Phosphorylation of Ryanodine Receptor Type 2 on Islet Calcium Handling, Insulin Secretion, and Glucose Tolerance

Altered insulin secretion contributes to the pathogenesis of type 2 diabetes. This alteration is correlated with altered intracellular Ca(2+)-handling in pancreatic β cells. Insulin secretion is triggered by elevation in cytoplasmic Ca(2+) concentration ([Ca(2+)](cyt)) of β cells. This elevation in...

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Main Authors: Dixit, Sayali S., Wang, Tiannan, Manzano, Eiffel John Q., Yoo, Shin, Lee, Jeongkyung, Chiang, David Y., Ryan, Nicole, Respress, Jonathan L., Yechoor, Vijay K., Wehrens, Xander H. T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596297/
https://ncbi.nlm.nih.gov/pubmed/23516528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058655
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