Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides

AIMS: Recent studies suggest that proarrhythmic effects of cardiac glycosides (CGs) on cardiomyocyte Ca(2+) handling involve generation of reactive oxygen species (ROS). However, the specific pathway(s) of ROS production and the subsequent downstream molecular events that mediate CG-dependent arrhyt...

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Detalhes bibliográficos
Main Authors: Ho, Hsiang-Ting, Liu, Bin, Snyder, Jedidiah S., Lou, Qing, Brundage, Elizabeth A., Velez-Cortes, Florencia, Wang, Honglan, Ziolo, Mark T., Anderson, Mark E., Sen, Chandan K., Wehrens, Xander H.T., Fedorov, Vadim V., Biesiadecki, Brandon J., Hund, Thomas J., Györke, Sándor
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868350/
https://ncbi.nlm.nih.gov/pubmed/24104877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvt233
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