Substrate Specificity of Protein Tyrosine Phosphatases 1B, RPTPα, SHP-1, and SHP-2

We determined the substrate specificities of the protein tyrosine phosphatases (PTPs) PTP1B, RPTPα, SHP-1, and SHP-2 by on-bead screening of combinatorial peptide libraries and solution-phase kinetic analysis of individually synthesized phosphotyrosyl (pY) peptides. These PTPs exhibit different leve...

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Main Authors: Ren, Lige, Chen, Xianwen, Luechapanichkul, Rinrada, Selner, Nicholas G., Meyer, Tiffany M., Wavreille, Anne-Sophie, Chan, Richard, Iorio, Caterina, Zhou, Xiang, Neel, Benjamin G., Pei, Dehua
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074353/
https://ncbi.nlm.nih.gov/pubmed/21291263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1014453
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