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Identification of Major Binding Proteins and Substrates for the SH2-Containing Protein Tyrosine Phosphatase SHP-1 in Macrophages

The protein tyrosine phosphatase SHP-1 is a critical regulator of macrophage biology, but its detailed mechanism of action remains largely undefined. SHP-1 associates with a 130-kDa tyrosyl-phosphorylated species (P130) in macrophages, suggesting that P130 might be an SHP-1 regulator and/or substrat...

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Bibliografiske detaljer
Main Authors: Timms, John F., Carlberg, Kristen, Gu, Haihua, Chen, Haiyan, Kamatkar, Shubhangi, Nadler, Monica J. S., Rohrschneider, Larry R., Neel, Benjamin G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC108968/
https://ncbi.nlm.nih.gov/pubmed/9632768
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