Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

Activating mutations in the Kit receptor tyrosine kinase have been identified in both rodent and human mast cell leukemia. One activating Kit mutation substitutes a valine for aspartic acid at codon 816 (D816V) and is frequently observed in human mastocytosis. Mutation at the equivalent position in...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Piao, Xianhua, Paulson, Robert, van der Geer, Peter, Pawson, Tony, Bernstein, Alan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26192/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962111/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14665
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