Specificity Profiling of Dual Specificity Phosphatase Vaccinia VH1-related (VHR) Reveals Two Distinct Substrate Binding Modes

Vaccinia VH1-related (VHR) is a dual specificity phosphatase that consists of only a single catalytic domain. Although several protein substrates have been identified for VHR, the elements that control the in vivo substrate specificity of this enzyme remain unclear. In this work, the in vitro substr...

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Detalhes bibliográficos
Main Authors: Luechapanichkul, Rinrada, Chen, Xianwen, Taha, Hashem A., Vyas, Shubham, Guan, Xiaoyan, Freitas, Michael A., Hadad, Christopher M., Pei, Dehua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585083/
https://ncbi.nlm.nih.gov/pubmed/23322772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.449611
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