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Synthesis of 3,5-Difluorotyrosine-Containing Peptides: Application in Substrate Profiling of Protein Tyrosine Phosphatases
[Image: see text] Fully protected 3,5-difluorotyrosine (F(2)Y), Fmoc-F(2)Y(tBu)-OH, is efficiently prepared by a chemo-enzymatic process and incorporated into individual peptides and combinatorial peptide libraries. The F(2)Y-containing peptides display similar kinetic properties toward protein tyro...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650251/ https://ncbi.nlm.nih.gov/pubmed/18798640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol801868a |
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