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Probing the Catalytic Mechanism of S-Ribosylhomocysteinase (LuxS) with Catalytic Intermediates and Substrate Analogues

S-Ribosylhomocysteinase (LuxS) cleaves the thioether bond in S-ribosylhomocysteine (SRH) to produce homocysteine (Hcys) and 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor of the type II bacterial quorum sensing molecule (AI-2). The catalytic mechanism of LuxS comprises of three distinct reactio...

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書誌詳細
主要な著者: Gopishetty, Bhaskar, Zhu, Jinge, Rajan, Rakhi, Sobczak, Adam J., Wnuk, Stanislaw F., Bell, Charles E., Pei, Dehua
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654206/
https://ncbi.nlm.nih.gov/pubmed/19099445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja808206w
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