Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position

S-Ribosylhomocysteinase (LuxS) catalyzes the cleavage of the thioether bond of S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD), which is the precursor of type 2 autoinducer for bacterial cell-cell communication. In this work, we have synthesized several S...

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Hlavní autoři: Wnuk, Stanislaw F., Robert, Jenay, Sobczak, Adam J., Meyers, Brandon P., Malladi, Venkata L.A., Zhu, Jinge, Gopishetty, Bhaskar, Pei, Dehua
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765115/
https://ncbi.nlm.nih.gov/pubmed/19682914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.07.057
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