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Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

Herein, we show that a naturally occurring RNA G-quadruplex element within the 5′ UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5′ UTR mRNA G-quadruplexes have potential as molec...

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Bibliografiske detaljer
Main Authors: Bugaut, Anthony, Rodriguez, Raphaël, Kumari, Sunita, Hsu, Shang-Te Danny, Balasubramanian, Shankar
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074098/
https://ncbi.nlm.nih.gov/pubmed/20436976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c002418j
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