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Position and Stability Are Determining Factors for Translation Repression by an RNA G-Quadruplex-Forming Sequence within the 5′ UTR of the NRAS Proto-oncogene

Nucleic acid secondary structures in the 5′ untranslated regions (UTRs) of mRNAs have been shown to play a critical role in translation regulation. We recently demonstrated that a naturally occurring, conserved, and stable RNA G-quadruplex element (5′-GGGAGGGGCGGGUCUGGG-3′), located close to the 5′...

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Detalhes bibliográficos
Main Authors: Kumari, Sunita, Bugaut, Anthony, Balasubramanian, Shankar
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746962/
https://ncbi.nlm.nih.gov/pubmed/18991403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8010797
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