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Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
Herein, we show that a naturally occurring RNA G-quadruplex element within the 5′ UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5′ UTR mRNA G-quadruplexes have potential as molec...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3074098/ https://ncbi.nlm.nih.gov/pubmed/20436976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c002418j |
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