Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2

Cyclooxygenase catalysis by prostaglandin H synthase (PGHS)-1 and -2 involves reaction of a peroxide-induced Tyr385 radical with arachidonic acid (AA) to form an AA radical that reacts with O(2). The potential for isomeric AA radicals and formation of an alternate tyrosyl radical at Tyr504 complicat...

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Bibliografiska uppgifter
Huvudupphovsmän: Tsai, Ah-lim, Wu, Gang, Rogge, Corina E., Lü, Jian-Ming, Peng, Sheng, van der Donk, Wilfred A., Palmer, Graham, Gerfen, Gary J., Kulmacz, Richard J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073652/
https://ncbi.nlm.nih.gov/pubmed/21421123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2010.11.012
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