Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases

Chemoradiation is the treatment of choice for locally advanced head and neck squamous cell carcinoma (HNSCC). However, radioresistance, which contributes to local recurrence, remains a significant therapeutic problem. In this study, we characterized SM-164, a small SMAC mimetic compound that promote...

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Main Authors: Yang, Jie, McEachern, Donna, Li, Wenyan, Davis, Mary A., Li, Hua, Morgan, Meredith A., Bai, Longchuan, Sebolt, Jonathan T., Sun, Haiying, Lawrence, Theodore S., Wang, Shaomeng, Sun, Yi
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073022/
https://ncbi.nlm.nih.gov/pubmed/21282353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0643
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