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Glycogen synthase kinase 3β mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1

High glucose (HG) has been shown to induce insulin resistance in both type 1 and type 2 diabetes. However, the molecular mechanism behind this phenomenon is unknown. Insulin receptor substrate (IRS) proteins are the key signaling molecules that mediate insulin’s intracellular actions. Genetic and bi...

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Bibliografiske detaljer
Main Authors: Leng, Sanhua, Zhang, Wenshuo, Zheng, Yanbin, Liberman, Ziva, Rhodes, Christopher J, Eldar-Finkelman, Hagit, Sun, Xiao Jian
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072280/
https://ncbi.nlm.nih.gov/pubmed/20466847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-09-0456
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