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Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates
The two main routes that cells use for degrading intracellular proteins are the ubiquitin-proteasome and autophagy-lysosome pathways, which have been thought to have largely distinct clients. Here, we show that autophagy inhibition increases levels of proteasome substrates. This is largely due to p6...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cell Press
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2669153/ https://ncbi.nlm.nih.gov/pubmed/19250912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.01.021 |
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