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Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

The two main routes that cells use for degrading intracellular proteins are the ubiquitin-proteasome and autophagy-lysosome pathways, which have been thought to have largely distinct clients. Here, we show that autophagy inhibition increases levels of proteasome substrates. This is largely due to p6...

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Detalhes bibliográficos
Main Authors: Korolchuk, Viktor I., Mansilla, Alicia, Menzies, Fiona M., Rubinsztein, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669153/
https://ncbi.nlm.nih.gov/pubmed/19250912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.01.021
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