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Genetic deletion of mPGES-1 abolishes PGE(2) production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migration
We undertook this study to determine the role of microsomal PGE synthase-1 (mPGES-1) and mPGES-1-generated prostaglandin (PG) E(2) on dendritic cell (DC) phenotype and function. Using mPGES-1 knockout (KO) mice, we generated bone marrow derived DCs and determined their eicosanoid production profile,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3072052/ https://ncbi.nlm.nih.gov/pubmed/21190819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.plefa.2010.10.003 |
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