mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis

INTRODUCTION: Microsomal prostaglandin E2 synthase-1 (mPGES-1) is an inducible enzyme that acts downstream of cyclooxygenase (COX) to specifically catalyze the conversion of prostaglandin (PG) H(2 )to PGE(2). mPGES-1 plays a key role in inflammation, pain and arthritis; however, the role of mPGES-1...

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Main Authors: McCann, Matthew R, Monemdjou, Roxana, Ghassemi-Kakroodi, Parisa, Fahmi, Hassan, Perez, Gemma, Liu, Shangxi, Shi-wen, Xu, Parapuram, Sunil K, Kojima, Fumiaki, Denton, Christopher P, Abraham, David J, Martel-Pelletier, Johanne, Crofford, Leslie J, Leask, Andrew, Kapoor, Mohit
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546456/
https://ncbi.nlm.nih.gov/pubmed/21266028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3226
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