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Homeoprotein Six1 Increases TGF–β Type I Receptor and Converts TGF-β Signaling from Suppressive to Supportive for Tumor Growth

The Six1 homeodomain protein is a developmental transcription factor that has been implicated in tumor onset and progression. Our recent work demonstrates that Six1 overexpression in human breast cancer cell lines is sufficient to induce epithelial-to-mesenchymal transition (EMT) and metastasis. Imp...

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Bibliografiske detaljer
Main Authors: Micalizzi, Douglas S., Wang, Chu-An, Farabaugh, Susan M., Schiemann, William P., Ford, Heide L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072046/
https://ncbi.nlm.nih.gov/pubmed/21056993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1354
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