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Homeoprotein Six1 Increases TGF–β Type I Receptor and Converts TGF-β Signaling from Suppressive to Supportive for Tumor Growth
The Six1 homeodomain protein is a developmental transcription factor that has been implicated in tumor onset and progression. Our recent work demonstrates that Six1 overexpression in human breast cancer cell lines is sufficient to induce epithelial-to-mesenchymal transition (EMT) and metastasis. Imp...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3072046/ https://ncbi.nlm.nih.gov/pubmed/21056993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1354 |
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