Eya2 Is Required to Mediate the Pro-Metastatic Functions of Six1 Via the Induction of TGF-β Signaling, Epithelial-Mesenchymal Transition, and Cancer Stem Cell Properties

Six1 is a critical regulator of embryonic development that requires interaction with the Eya family of proteins (Eya1-4) to activate the transcription of genes involved in neurogenesis, myogenesis, and nephrogenesis. While expression of Six1 and Eya family members is predominantly observed in develo...

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Autores principales: Farabaugh, Susan M., Micalizzi, Douglas S., Jedlicka, Paul, Zhao, Rui, Ford, Heide L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183358/
https://ncbi.nlm.nih.gov/pubmed/21706047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.259
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