Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition

Six1 is a developmentally regulated homeoprotein with limited expression in most normal adult tissues and frequent misexpression in a variety of malignancies. Here we demonstrate, using a bitransgenic mouse model, that misexpression of human Six1 in adult mouse mammary gland epithelium induces tumor...

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Detalhes bibliográficos
Main Authors: McCoy, Erica L., Iwanaga, Ritsuko, Jedlicka, Paul, Abbey, Nee-Shamo, Chodosh, Lewis A., Heichman, Karen A., Welm, Alana L., Ford, Heide L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735909/
https://ncbi.nlm.nih.gov/pubmed/19726883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37691
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