Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways

INTRODUCTION: Mammary-specific overexpression of Six1 in mice induces tumors that resemble human breast cancer, some having undergone epithelial to mesenchymal transition (EMT) and exhibiting stem/progenitor cell features. Six1 overexpression in human breast cancer cells promotes EMT and metastatic...

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Main Authors: Iwanaga, Ritsuko, Wang, Chu-An, Micalizzi, Douglas S, Harrell, J Chuck, Jedlicka, Paul, Sartorius, Carol A, Kabos, Peter, Farabaugh, Susan M, Bradford, Andrew P, Ford, Heide L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680936/
https://ncbi.nlm.nih.gov/pubmed/22765220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3219
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