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The secondary structure and sequence optimization of an RNA ligase ribozyme.
In vitro selection can generate functional sequence variants of an RNA structural motif that are useful for comparative analysis. The technique is particularly valuable in cases where natural variation is unavailable or non-existent. We report the extension of this approach to a new extreme--the ide...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1995
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC307182/ https://ncbi.nlm.nih.gov/pubmed/7667099 |
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