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Structure-guided engineering of the regioselectivity of RNA ligase ribozymes

Ribozyme-catalyzed RNA synthesis is central to the RNA world hypothesis. No natural RNA polymerase ribozymes have been discovered. However, ribozymes that catalyze the requisite chemistry, generating a new phosphodiester through attack of a terminal hydroxyl of an RNA on the α-phosphate of a triphos...

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Autors principals: Pitt, Jason N., Ferré-D'Amaré, Adrian R.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678027/
https://ncbi.nlm.nih.gov/pubmed/19220054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8067325
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