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Structure-guided engineering of the regioselectivity of RNA ligase ribozymes
Ribozyme-catalyzed RNA synthesis is central to the RNA world hypothesis. No natural RNA polymerase ribozymes have been discovered. However, ribozymes that catalyze the requisite chemistry, generating a new phosphodiester through attack of a terminal hydroxyl of an RNA on the α-phosphate of a triphos...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2678027/ https://ncbi.nlm.nih.gov/pubmed/19220054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8067325 |
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