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Rapid Construction of Empirical RNA Fitness Landscapes

Evolution is an adaptive walk through a hypothetical fitness landscape, which depicts the relationship between genotypes and the fitness of each corresponding phenotype. We constructed an empirical fitness landscape for a catalytic RNA by combining next-generation sequencing, computational analysis...

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Autors principals: Pitt, Jason N., Ferré-D’Amaré, Adrian R.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392653/
https://ncbi.nlm.nih.gov/pubmed/20947767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1192001
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