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RNA binding: getting specific about specificity

Sequence-specific nucleic acid binding proteins do not recognize one sequence out of all possibilities; rather, they bind with a range of affinities to many. By combining randomization and deep sequencing, Lin et al. have experimentally described the landscape relating sequence to affinity of an RNA...

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Publicat a:Cell Chem Biol
Autor principal: Ferré-D'Amaré, Adrian R.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187952/
https://ncbi.nlm.nih.gov/pubmed/27768867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.10.001
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