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Binding Between G-quadruplexes at the Homodimer Interface of the Corn RNA Aptamer Strongly Activates Thioflavin T Fluorescence

Thioflavin T (ThT) is widely used for the detection of amyloids. Many unrelated DNAs and RNAs that contain G-quadruplex motifs also bind ThT, and strongly activate its fluorescence. To elucidate the structural basis of ThT binding to G-quadruplexes and its fluorescence turn-on, we determined its co-...

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Bibliografiske detaljer
Udgivet i:Cell Chem Biol
Main Authors: Sjekloća, Ljiljana, Ferré-D’Amaré, Adrian R.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697623/
https://ncbi.nlm.nih.gov/pubmed/31178406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.04.012
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