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Binding Between G-quadruplexes at the Homodimer Interface of the Corn RNA Aptamer Strongly Activates Thioflavin T Fluorescence
Thioflavin T (ThT) is widely used for the detection of amyloids. Many unrelated DNAs and RNAs that contain G-quadruplex motifs also bind ThT, and strongly activate its fluorescence. To elucidate the structural basis of ThT binding to G-quadruplexes and its fluorescence turn-on, we determined its co-...
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| Published in: | Cell Chem Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6697623/ https://ncbi.nlm.nih.gov/pubmed/31178406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.04.012 |
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