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Structural basis for specific, high-affinity tetracycline binding by an in vitro evolved aptamer and artificial riboswitch

The tetracycline aptamer is an in vitro selected RNA that binds to the antibiotic with the highest known affinity of an artificial RNA for a small molecule (K(d) ~ 0.8 nM). It is one of few aptamers known to be capable of modulating gene expression in vivo. The 2.2 Å-resolution cocrystal structure o...

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Detaylı Bibliyografya
Asıl Yazarlar: Xiao, Hong, Edwards, Thomas E., Ferré-D'Amaré, Adrian R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626642/
https://ncbi.nlm.nih.gov/pubmed/18940672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.09.004
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