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Increased IGF-1 in muscle modulates the phenotype of severe SMA mice

Spinal muscular atrophy (SMA) is an inherited motor neuron disease caused by the mutation of the survival motor neuron 1 (SMN1) gene and deficiency of the SMN protein. Severe SMA mice have abnormal motor function and small, immature myofibers early in development suggesting that SMN protein deficien...

詳細記述

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書誌詳細
主要な著者: Bosch-Marcé, Marta, Wee, Claribel D., Martinez, Tara L., Lipkes, Celeste E., Choe, Dong W., Kong, Lingling, Van Meerbeke, James P., Musarò, Antonio, Sumner, Charlotte J.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071675/
https://ncbi.nlm.nih.gov/pubmed/21325354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr067
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