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Product and Mechanistic Analysis of the Reactivity of a C6-Pyrimidine Radical in RNA

Nucleobase radicals are the major reactive intermediates produced when hydroxyl radical reacts with nucleic acids. 5,6-Dihydrouridin-6-yl radical (1) was independently generated from a ketone precursor via Norrish Type I photocleavage in a dinucleotide, single stranded, and double stranded RNA. This...

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Bibliografiske detaljer
Main Authors: Jacobs, Aaron C., Resendiz, Marino J. E., Greenberg, Marc M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071645/
https://ncbi.nlm.nih.gov/pubmed/21391681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja200317w
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