NK1.1(+) Cells and CD8(+) T Cells Mediate the Antitumor Activity of Cl-IB-MECA in a Mouse Melanoma Model

Cl-IB-MECA, synthetic A(3) adenosine receptor agonist, is a potential anticancer agent. In this study, we have examined the effect of Cl-IB-MECA in a mouse melanoma model. Cl-IB-MECA significantly inhibited tumor growth in immune-competent mice. Notably, the number of tumor-infiltrating NK1.1(+) cel...

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Main Authors: Morello, Silvana, Sorrentino, Rosalinda, Montinaro, Antonella, Luciano, Antonio, Maiolino, Piera, Ngkelo, Anta, Arra, Claudio, Adcock, Ian M, Pinto, Aldo
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071085/
https://ncbi.nlm.nih.gov/pubmed/21472141
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