The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

Despite the fact that X-box binding protein-1 (XBP-1) is one of the main regulators of the unfolded protein response (UPR), the modulators of XBP-1 are poorly understood. Here, we show that the regulatory subunits of phosphotidyl inositol 3-kinase (PI3K), p85α (encoded by Pik3r1) and p85β (encoded b...

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Hlavní autoři: Park, Sang Won, Zhou, Yingjiang, Lee, Justin, Lu, Allen, Sun, Cheng, Chung, Jason, Ueki, Kohjiro, Ozcan, Umut
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071012/
https://ncbi.nlm.nih.gov/pubmed/20348926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2099
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