Evolution of CCR5 Antagonist Resistance in an HIV-1 Subtype C Clinical Isolate

OBJECTIVES: We previously reported vicriviroc (VCV) resistance in an HIV-infected subject and used deep sequencing and clonal analyses to track the evolution of V3 sequence forms over 28 weeks of therapy. Here, we test the contribution of gp120 mutations to CCR5 antagonist resistance and investigate...

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Main Authors: Henrich, Timothy J., Tsibris, Athe M.N., Lewine, Nicolas R.P., Konstantinidis, Ioannis, Leopold, Kay E., Sagar, Manish, Kuritzkes, Daniel R.
格式: Artigo
語言:Inglês
出版: 2010
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070184/
https://ncbi.nlm.nih.gov/pubmed/20856130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e3181f25574
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