HIV-1 Clinical Isolates Resistant to CCR5 Antagonists Exhibit Delayed Entry Kinetics That Are Corrected in the Presence of Drug

HIV CCR5 antagonists select for env gene mutations that enable virus entry via drug-bound coreceptor. To investigate the mechanisms responsible for viral adaptation to drug-bound coreceptor-mediated entry, we studied viral isolates from three participants who developed CCR5 antagonist resistance dur...

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Detalhes bibliográficos
Main Authors: Putcharoen, Opass, Lee, Sun Hee, Henrich, Timothy J., Hu, Zixin, Vanichanan, Jakapat, Coakley, Eoin, Greaves, Wayne, Gulick, Roy M., Kuritzkes, Daniel R., Tsibris, Athe M. N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255837/
https://ncbi.nlm.nih.gov/pubmed/22090117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06421-11
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